home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410m.zip
/
M94A2373.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
3KB
|
51 lines
Document 2373
DOCN M94A2373
TI Prognostic markers of immune decline in the case of a HIV-1 infected man
with a pre-existing autoimmune disorder.
DT 9412
AU Douvas A; Takehana Y; Ehresmann G; Univ. of Southern Calif. School of
Med. Los Angeles.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):319 (abstract no. PC0208). Unique
Identifier : AIDSLINE ICA10/94370202
AB OBJECTIVE: We tested the hypothesis that a pre-existing autoimmune
disorder, which mimics early HIV-1 infection, provides immunologic
markers prognostic of a decline in CD4+ T lymphocytes. METHODS: We have
established that the autoimmune disorder mixed connective tissue disease
(MCTD) mimics early HIV-1 infection in several respects. In particular,
there is structural homology between the autoimmune antigen 70K (a RNA
splicing protein) and gp120/41. This results in cross-reactivity between
anti-70K antibodies and gp120/41. Conversely, HIV-1(+) sera cross-react
with 70K. Here we present a longitudinal study of a 43 year old man,
patient M, with a 27-year history of MCTD, who became HIV infected
between 7/85 and 10/86. Sera from 1981 to 1994 were analyzed for
reactivity to HIV-1 by ELISA and WB, and for reactivity to gp120, gp41
and the V3 loop (both IIIB and MN strains) by ELISA. Analysis of
reactivity to 70K was performed by ELISA and WB. The data were
correlated with CD4+ T lymphocyte counts. Single serum samples from 12
HIV-1 infected men with no pre-existing autoimmunity were analyzed for
comparison. RESULTS: Between 10/86 (date of seroconversion) and 6/87,
patient M's 70K WB declined to 47% of the 1981 level, with no changes in
other immunologic parameters. Between 6/87 and 5/89, the 70K ELISA
further declined 2.1 fold while CD4 counts were stable at 504 and 543,
respectively. In 3/93, the 70K WB was 12.5% of the 1981 level (CD4 count
= 268). All HIV-1 ELISA values remained unchanged between 1986 and 1994
except for the V3 IIIB ELISA, which declined between 5/89 and 12/93 to
33% of maximal value. The 12 HIV-1 infected controls were positive in
all immunologic tests, including 70K ELISA and WB. CONCLUSIONS: A rapid
decline in reactivity to 70K in the serum of patient M (to 47% of
maximum) occurred less than one year from diagnosis of HIV(+) status. A
further decline to 22% of maximum occurred in 5/89. CD4 counts remained
stable in the 500 range between 7/87 and 12/92. These data suggest that
a decline in 70K reactivity in all HIV-1(+) sera, may precede the
decline in CD4+ T cells by months to years.
DE Adult Autoantigens/IMMUNOLOGY Autoimmune
Diseases/*COMPLICATIONS/IMMUNOLOGY Enzyme-Linked Immunosorbent Assay
Human HIV Antibodies/ANALYSIS HIV Infections/COMPLICATIONS/*IMMUNOLOGY
HIV Seropositivity *HIV-1/IMMUNOLOGY Leukocyte Count Male Mixed
Connective Tissue Disease/*COMPLICATIONS Prognosis T4 Lymphocytes
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).